整合素β1、FAK和pY397FAK在非小细胞肺癌组织中的表达

Significance and expression of Integrin β1,focal adhesion kinase(FAK) and phosphorylated focal adhesion kinase(pY397FAK) in non-small cell lung cancer

通过检测整合素β1亚基、FAK和其磷酸化形式pY397FAK在非小细胞肺癌(non-small cell lung cancer,NSCLC)和正常支气管黏膜上皮中的表达,探讨整合素β1与FAK在NSCLC发生、浸润和转移中的作用。应用免疫组织化学方法检测整合素β1、FAK和pY397FAK在72例NSCLC、29例淋巴结转移癌和19例正常支气管黏膜上皮中的表达,并与临床病理指标结合起来进行分析。

To explore the roles of Integrin β1, FAK and its phosphorylated form, i. e. pY397FAK, in tumorigenesis, invasion and metastasis of non-small cell lung cancer （NSCLC） by detecting the expression of Integrin β1, FAK and pY397FAK in human normal bronchial epithelium, primary NSCLC and matched lymph node （LN） metastases. Using immunohistochemical method, the expression of Integrin 131, FAK and pY397FAK in 72 cancerous tissues and 29 LN metastases as well as 19 normal bronchial epithelia was measured. The relationship between Integrin β1, FAK and pY397FAK expression and clinicopathological characteristics was analyzed.