银杏达莫对慢性肺源性心脏病肺动脉高压的影响

The effect of ginkgodipyidamlum on pulmonary hypretension in patients with chronic pulmonary heart disease

目的探讨银杏达莫对慢性肺源性心脏病患者肺动脉高压的影响。方法将42例缓解期肺源性心脏病患者分为两组,治疗组27例,银杏达莫15～20ml加入5%葡萄糖糖液200～300ml静脉滴注,1次/d;对照组15例,静脉滴注安慰剂,每日1次。两组病例于治疗前、治疗第14天和第28天时分别做心脏彩超1次,测三尖瓣区血液反流速度(Vt),计算出收缩期肺动脉压(SpAp)。结果统计学分析显示治疗组治疗后Vt下降明显(P<0.01),Vt2/SpAp有显著下降(P<0.05);对照组治疗前后各指标无明显变化,两组比较,银杏达莫与安慰剂治疗效果比较差异有统计学意义。结论本研究表明银杏达莫可显著降低SpAp,可用于肺源性心脏病的治疗。

Objective To investigate the effect of ginkgodipyidamlum on pulmonary hypertension in patie,,s with chronic pul- monary heart disease （ CPHD ）. Methods Forty - two patients in stable stage were divided into 2 groups ： （1）treatment group （n = 27） received ginkgodipyidamlum. （2）control placebo group （ n = 15 ）. Color Doppler echocardiographies were carried out before treatment and at 14th,28th days during treatment to measure the velocity of blood backtlow at tricuspid valve （Vt）, and calculate the xystolic pulmonary arterial pressure （SpAp）. Results Vt/Vt2 and SpAp decreased significantly in treatment group as compared with control group （ P 〈 0.05）. Conclusion Ginkgodipyidamlum can decrease SpAp obviously and is a drug of choice for prevent and treatment of CPHD.