成人慢性上颌窦炎的细菌学研究及药敏观察

Bacteriological study of chronic maxillary sinusitis in adults and observation of susceptibility to antibiotics

为研究成人慢性上颌窦炎的细菌分布及分离菌株对常用抗生素的敏感性。对 4 2例成人慢性上颌窦炎患者的单侧病窦粘膜进行细菌培养、药敏试验及产β-内酰胺酶细菌 (βL PB)鉴定。结果发现 85.71%标本有细菌生长 ,9例 ( 2 1.4 3% )分离出厌氧菌 ,33例 ( 78.57% )分离出需氧菌。βL PB阳性率高达 4 0 % ,和细菌的耐药性有关。分离细菌对含 β-内酰胺酶抑制剂的抗生素、三代头孢菌素类药物及三代喹诺酮类药物有较高敏感性。揭示细菌感染在慢性鼻窦炎的发病中可能不占关键地位。在行抗生素治疗时需考虑由于

The unilateral mucosal samples were taken from 42 patients and were cultured for bacterial.Meanwhile,the antimicrobial susceptibility was determined for 11 antibiotics and the β lactamase producing bacteria(βLPB) were examined.In 85.71% of all samples,bacterial growth was present.Anaerobic bacteria were present in 21.43% of cases.Predominant aerobic bacteria were α hemolytic streptococci and coagulase negative staphylococci.Predominant anaerobic bacteria were peptostreptococcus species and bacteroides species.The βLPB were isolated from 40% patients,which were responsible for the resistance to some antibiotics.The antimicrobial susceptibility testing showed that the antibiotics containing β lactamase inhibitor,third generation cephalosporins and third generation quinolones had good efficacy.Our findings indicated the bacterial infection may not play the key role in the development of chronic sinusitis and that the bacterial infection may not play the key role in the development of chronic sinustis and the resistance to some antibiotics due to the high prevalence of β lactamase production must be considered when the antibiotics therapy is taken.