利培酮治疗首发精神分裂症疗效观察2年随访

The clinical observation of Risperidone on first - onset patients with schizophrenia

目的:观察利培酮治疗首发精神分裂症患者长期疗效。方法:入组40例首发精神分裂症患者,给予利培酮治疗并随访2年,采用阳性与阴性症状量表评估临床疗效。结果:利培酮治疗第2周末起PANSS评分显著低于治疗前(P<0.05);第6、12、24月末总有效率依次是82.5%、75.0%和72.5%,第12、24月末复发率分别是7.5%和10.0%。结论:利培酮维持治疗精神分裂症有效,并可以降低复发率。

Objective：To investigate the long -term effect of Risperidone on first -onset patients with schizophrenia. Methods：40 first- onset patients with schizophrenia were included, treated with Risperidone for 2 years and evaluated with PANSS. Resuits： Since the second weekend after treatment of Risperidone, the scores of PANSS were notably lower than that before treatment （ P 〈 0.05）. The total response rates on the 6th, 12th, 24th month were respectively 82.5% , 75.0% and 72.5% , the relapse rates on 12th and 24th were respectively 7.5% and 10.0%. Conclusions ： Risperidone is effective on the maintenance of schizophrenia and decrease the relapse rate.