帕罗西汀合并奥氮平治疗难治性抑郁症疗效观察

A comparative study of Paroxetine combined with Olanzapine in the treatment of refractory depression

目的:探讨帕罗西汀合并奥氮平治疗难治性抑郁症的疗效及安全性。方法:将58例难治性抑郁症患者随机分为研究组(帕罗西汀合并奥氮平治疗)和对照组(单用帕罗西汀治疗),疗程8周。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效和不良反应。结果:治疗后两组HAMD、HAMA评分均较治疗前有显著降低(P<0.05)。治疗后第2、4、6、8周末,研究组的HAMD和HAMA评分均显著低于对照组,差异具有显著性(P<0.05或P<0.01)。两组不良反应均较轻微。结论:帕罗西汀合并奥氮平治疗难治性抑郁症较单用帕罗西汀具有疗效好、起效快、不良反应少、患者依从性好的特点。

Objective：To explore the efficacy and safety of Paroxetine combined with Olanzapine in the treatment of refractory depression. Methods：A total of 58 patients with refractory depression were randomly divided into study group with Paroxetine combined with Olanzapine and control group with Paroxetine for 8 weeks of treatment. The clinical efficacy and side effects were assessed with Hamilton Depression Scale （HAMD）, Hamilton Anxiety Scale （HAMA） and Treatment Emergent symptom Scale （TESS）. Results： After treatment, the scores of HAMD and HAMA in two groups were both significantly lower than those before treatment, In the 2nd , 4th ,6th ,and 8th weekend of treatment, the scores of HAMD and HAMA in study group were significantly lower than those in control group. No severe side effects were found in two groups. Conclusions： Paroxetine augmented with Olanzapine takes effects better and faster than Paroxetine single and doesnt increase side effects in the treatment of refractory depression.