摘要
目的:研究文拉法辛缓释胶囊和氯丙咪嗪治疗惊恐障碍的有效性和安全性。方法:随机对照的研究,为期10周。以临床判断及PASS、HAMA、HAMD等量表评定临床效果,以TESS评定不良反应。结果:入组73例(文拉法辛缓释胶囊38例,氯丙咪嗪35例),因不良反应而退组5例(分别为1例和4例),完成研究者68例(分别为37例和31例)。平均最高剂量为:文拉法辛缓释胶囊163.5 mg/d,氯丙咪嗪159.7 mg/d。疗效判断,文拉法辛缓释胶囊和氯丙咪嗪的显效率为62.2%和64.5%,两种药物的效果无明显差异。不良反应的发生率,文拉法辛缓释胶囊组18.4%,远低于氯丙咪嗪组的42.9%。结论:文拉法辛缓释胶囊是一种疗效好、安全性高的治疗惊恐障碍的药物。
Objective: To compare the efficacy and safety of Venlafaxine HCI and Clomipramine in the treatment of panic disorder. Methods: A 10 weeks randomized study was designed. The efficacy was evaluated by clinical judgment, PANSS, HAMA and HAMD. The safety was assessed in terms of TESS. Results: 73 cases of panic disorder were enrolled and 5 cases were withdrawn due to intolerance of side effects : 1 case from group of Venlafaxine and 4 cases from group of Clomipramine, Among complete cases, 37 were in the treatment of Venlafaxine and 31 were in Clomipramine, According the judgment of clinicians, the marked i improved rate was 62.2% for Venlafaxine and 64.5% for Clomipramine. However, there was no significant difference in any efficacy measurement between two groups. Venlafaxine group had much lower incidence of side effect( 18.7% )than that of Clomipramine (42.9%). Conclusions: Venlafaxine HCI is one of efficient and high - safety drug in treatment of panic disorder.
出处
《中国民康医学》
2009年第23期2978-2980,共3页
Medical Journal of Chinese People’s Health
关键词
文拉法辛
氯丙咪嗪
惊恐障碍
Venlafaxine
Clomipramine
Treatment
Panic
Disorder