胃肠道间质瘤组织中MMP-13与CD147的表达及其意义

EXPRESSIONS OF CD147 AND MATRIX METALLOPROTEINASE-13 IN GASTROINTESTINAL STROMAL TUMORS AND THEIR SIGNIFICANCE

目的探讨基质金属蛋白酶-13(Matrix metalloproteinases-13,MMP-13)和CD147的表达与胃肠道间质瘤(Gastrointestinals stromal tumors,GISTs)临床病理特征的关系。方法采用免疫组织化学检测69例GISTs组织中MMP-13及CD147的表达,分析MMP-13和CD147与各病理参数的关系。结果GISTs组织中MMP-13和CD147的表达率分别为95.7%和97.1%,MMP-13阳性表达程度与GISTs的生物学行为、CD147表达及肿瘤的大小呈正相关(P<0.05);CD147阳性表达程度与肿瘤的大小呈正相关(P<0.05)。结论MMP-13表达与GISTs生物学行为关系密切,可作为GISTs生物学行为的潜在评价指标。

Objective To investigate the relationship between the expression of matrix metalloproteinase-13 and CD147 and their clinical significance in gastrointestinal stromal tumors（GISTs）.Methods 69 cases of GISTs were immunohistochemically studied for the expressions of MMP-13 and CD147 and their relations with every pathologic parameter were analyzed statistically.ResultsOut of 69 cases,the positivity of MMP-13 and CD147 was 95.7% and 97.1 % respectively.The expression degree of MMP-13 was significantly related to the biological behavior,the expression degree of CD147 and the size of tumors（P 〈0.05）.The expression degree of CD147 was significantly related to the size of tumors（P〈0.05）.ConclusionMMP-13 is closely related with the biological behavior of GISTs,and it might be a potential evaluation marker for GIST behavior.