摘要
目的探讨基质金属蛋白酶-13(Matrix metalloproteinases-13,MMP-13)和CD147的表达与胃肠道间质瘤(Gastrointestinals stromal tumors,GISTs)临床病理特征的关系。方法采用免疫组织化学检测69例GISTs组织中MMP-13及CD147的表达,分析MMP-13和CD147与各病理参数的关系。结果GISTs组织中MMP-13和CD147的表达率分别为95.7%和97.1%,MMP-13阳性表达程度与GISTs的生物学行为、CD147表达及肿瘤的大小呈正相关(P<0.05);CD147阳性表达程度与肿瘤的大小呈正相关(P<0.05)。结论MMP-13表达与GISTs生物学行为关系密切,可作为GISTs生物学行为的潜在评价指标。
Objective To investigate the relationship between the expression of matrix metalloproteinase-13 and CD147 and their clinical significance in gastrointestinal stromal tumors(GISTs).Methods 69 cases of GISTs were immunohistochemically studied for the expressions of MMP-13 and CD147 and their relations with every pathologic parameter were analyzed statistically.ResultsOut of 69 cases,the positivity of MMP-13 and CD147 was 95.7% and 97.1 % respectively.The expression degree of MMP-13 was significantly related to the biological behavior,the expression degree of CD147 and the size of tumors(P 〈0.05).The expression degree of CD147 was significantly related to the size of tumors(P〈0.05).ConclusionMMP-13 is closely related with the biological behavior of GISTs,and it might be a potential evaluation marker for GIST behavior.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2009年第6期649-652,共4页
Chinese Journal of Histochemistry and Cytochemistry
基金
安徽省教育厅自然科学研究基金资助课题(2006KJ149c)
关键词
胃肠道间质瘤
基质金属蛋白酶-13
CD147
免疫组化
组织芯片
Gastrointestinal stromal tumor(GIST)
Matrix metalloproteinase(MMP)-13
CD147
Immunohistochemisty
Tissue microarray