β-环糊精与石枳菊挥发油包合物的制备及表征分析

Preparation and characterization of Acorus tatarinowii schott,Fructus Aurantii immaturus and Chrysanthemum morifolium compound essential oil/β-cyclodextrin complex

目的制备石菖蒲、菊花、枳实混合挥发油与β-环糊精(β-CD)的包合物并确证包合物的形成。方法采用研磨法制备混合挥发油/β-CD包合物,测定包合率和收率;通过扫描电镜、红外光谱、示差扫描量热法、气相色谱等方法考察挥发油/β-CD包合前后的变化。结果研磨法制得包合物的包合率为75.3%、收率为67.77%。扫描电镜、示差扫描量热法、红外光谱法、气相色谱法均确证包合物已形成。结论表征不仅可作为判断主客体相互作用的指征,而且可以提供制剂质量的控制依据。

OBJECTIVE To prepare and identify Acorus tatarinowii schott, Fruetus Aurantii immaturus and Chrysanthemum morifolium compound essential oil/β- cyclodextrin inclusion complex. METHODS The essential oil/β- cyclodextrin complex was prepared by kneading method. The essential oil/β- cyclodextrin complex, β- cyclodextrin （ β- CD） and kneading - induced characteristics were investigated by scanning electron microscopy（ SEM ）, differential scanning calorimetry （DSC）, IR and GC. RESULTS The complex inclusion rate of essential oil/β- CD complex was 75.3% , and the complex recovery was 67.7%. The formation of essential oil/β- CD complex was proved by the results of SEM, DSC, IR and GC analysis. The results showed the inclusion was prepared and identified. CONCLUSION The resultants data provided the evidences not only to the interaction between the host and guest, but also to provide scientific basis for quality control.