外阴皮肤和黏膜上皮非瘤样病变诊治现状

Current status of diagnosis and treatment of nonneoplastic epithelial disorders of the vulvar skin and mucosa

外阴皮肤和黏膜上皮非瘤样病变是指女性外阴皮肤和黏膜组织发生变性及色素改变的一组慢性疾病。目前认为自身免疫可能与硬化性苔藓发生关系密切;掌握早期和充分发展期硬化性苔藓的病理分类,有利于治疗时机的把握;超强效的糖皮质激素可用于治疗硬化性苔藓,是儿童硬化性苔藓治疗的一线药物;聚焦超声和中药等多种方法治疗均有效,但至今尚无一套公认的最佳治疗方案。

Nonneoplastic epithelial disorders of the vulvar skin and mucosa is a chronic mucocutaneous tissue degeneration and depigrnentation affecting vulvar skin and mucous. Abnormal autoimmunity may cause Lichen sclerosus （LS）. LS was divided early stage and advanced stage in pathology, response to treatment was varied according to the stage of the lesions where better results were seen in the early stages. Ultrapotent topical corticosteroids are used for the treatment of LS, which are first line in children. Many treatments including Focused ultrasound and Chinese medicine are effective, but there are no the best method for treatment by now.