干扰素联合化疗对卵巢浆液性囊腺癌Ⅲ期患者预后的影响

Clinical effect analysis of the adjuvant chemotheropy containing IFN on patients with ovarian serous cystadenocarcinoma in stage Ⅲ.

目的探讨干扰素(IFN)联合CP方案(环磷酰胺+卡铂)化疗对卵巢浆液性囊腺癌Ⅲ期患者预后的影响。方法选取中国医科大学附属第一医院妇科1998年1月至2004年6月收治的79例原发性卵巢浆液性囊腺癌Ⅲ期患者,随访成功者58例,按化疗疗程数以及是否应用干扰素分成3组(Ⅰ组26例,为术后未给予化疗或CP方案化疗次数<6次;Ⅱ组14例,为术后仅接受CP方案化疗次数≥6次;Ⅲ组18例,为术后接受CP方案联合干扰素化疗次数≥6次),比较3组生存率、近期疗效(1年)的关系。结果3组患者随访1～120个月,失访21例,随访率73.42%。Ⅰ～Ⅲ组1年生存率分别为73.08%、92.86%、94.44%,3年生存率分别为19.23%、57.14%、66.67%,5年生存率分别为11.54%、35.71%、38.89%,3组患者生存率比较差异有统计学意义(P<0.05)。Ⅱ、Ⅲ组患者生存率比较差异无统计学意义(P>0.05),但近期疗效存在明显差异(P<0.05)。结论术后足够疗程CP方案或CP方案联合干扰素治疗卵巢浆液性囊腺癌可以显著提高患者生存率;联合应用干扰素化疗未能显著提高患者生存率,但可以明显提高其近期疗效。

Objective To analyse and investigate the effects and prognosis in the use of adjuvant chemotherapy containing IFN on patients with ovarian serous cystadenocarcinoma after surgery. Methods Choose the 79 patients with primary ovarian serous cystadenocarcinoma in stage Ⅲ who were treated in gynecology department of our hospital during Jan, 1998 2004 ,and make them into 3 groups based on the courses of chemotherapy and whether they were treated combining with IFN（Group Ⅰ is the patients who received chemotherapy courses less than six;group Ⅱ is the patients received chemotherapy of CTX and CBP,and the courses is more than six;group m is the patients who reveived chomotherapy of CTX, CBP and IFN,and the courses is more than six） . Compare the difference of survival rate and recent therapeutic effect between the 3 groups. Results all the patients were followed up by 1 to 120 months. We loss 21 patients till now. One-year survival rate of the 3 groups were： 73.08% ,92.86% ,94.44% ;Three-year survival rate were： 19.23% ,57. 14% ,66. 67% ;Five-year survival rate were： 11.54% ,35.71% ,38.89% o The survival rates and recent therapeutic： effect were distinctly different between the patients who received different courses of chemotherapy （P 〈 0.05 ）. There is no distinct increase in the survival rate when the patients received adjuvant chemotherapy containing IFN（ P 〉 0.05 ）. Conclusion The survival rate can be increased obvously when the patients receive enough courses of chemotheropy;the survival rate can not be improved significantly in patients treated by CTX,CBP and IFN compared with threatment of CTX and CBP, but the recent （one-year） therapeutic effect can be improved significantly. The residual turner size and the courses of chemotherapy have some connection with the prognosis.