慢性阻塞性肺疾病的睡眠相关低氧

Sleep-related hypoxemia in chronic obstructive pulmonary disease

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者的夜间低氧问题从50年以前就认识到了。在许多COPD患者的多导睡眠监测研究中，研究者发现患者的睡眠潜伏期延长，总睡眠时间减少，慢波睡眠减少，快速动眼睡眠减少，还有一个最为重要的问题就是睡眠相关低氧（SRH）。本文主要对COPD患者SRH的定义、原因、患病率、严重程度、意义以及治疗等相关问题作一综述。

The phenomenon of nocturnal hypoxemia complicating chronic obstructive pulmonary disease（COPD） has been recognized for at least 50 years. Increased sleep latency, decreased total sleep time,decreased slow-wave sleep, decreased rapid eye movement sleep, and the most important, sleeprelated hypoxemia（SRH） have been noted in many polysomnographic studies of patients with COPD. In this mini review, the definition, reasons, prevalence, intensity, significance and treatments of SRH in COPD are summarized.