口服米索前列醇联合缩宫素预防产后出血的临床观察

Using oral misoprostoi and oxytocin to prevent postpartum hemorrhage

目的观察口服米索前列醇联合缩宫素预防及减少产后出血的临床效果。方法将足月妊娠正常分娩、单胎、头位无并发症产妇300例，随机分成三组，每组100例，分别分为口服米索前列醇联合缩宫素给药组（实验组），单纯缩宫素给药组（对照组A）及口服米索前列醇给药组（对照组B）。观察三组产后出血量，用药前后血压变化及不良反应的发生情况。结果实验纽子宫收缩明显加强，产后出血量明显少于对照组（P〈0．01），各组产妇用药产后的血压变化差异无统计意义（P〉0．05）。结论 口服米索前列醇联合缩宫索可有效减少产后出血量，且不良反应少，对血压无明显影响，方法简易，安全。

Objective To observe the clinical results of using oral misoprostol and oxytocin to prevent or reduce postpartum hemorrhage. Methods Choosed 300 cases of lying - in woman with full - term pregnancy, normal labor, born singly and no head complications ,whom were divided into three groups which were set up including 100 individuals. There were oral misoprostol and oxytocin（ experimental group）, oxytocin - singly（ controlled group A）, and oral misoprostol（ controlled group B）. To observe the amount of bleeding,how blood pressure had changed and the minus effects. Results Ex- perimental group＇ s uterine contraction showed significantly increased, amount of bleeding of the experimental group was obviously less than the controlled group＇ s（ P 〈0.01 ） , and the blood pressure changed was no statistical significance（ P 〉 0. 05）. Conclusions Therefore, using oral misoprostol and oxytocin can effectively decrease postpartum hemorrhage with lack some of the side effects, and does not affect the blood pressure, safety and easy operation.