高尿酸血症与代谢综合征及其组分的关系

Relationship between hyperuricemia and metabolic syndrome and its components

目的探讨高尿酸血症与代谢综合征（MS）及其组分的关系。方法采取随机多级分层整群抽样方法对来我院体检的442例18岁以上成人进行调查，其中高尿酸血症组218例，正常血尿酸组224例，分别测定两组的空腹血糖、血脂、血尿酸、血压和体重指数，统计两组的代谢综合征及其各组分的患病率。结果高尿酸血症组空腹血糖、血甘油三酯、总胆固醇、低密度脂蛋白、血压、体重指数均值均高于正常血尿酸组，差异有统计学意义（P〈0．01）；高尿酸血症组超重或肥胖、高血脂、高血压、高血糖及代谢综合征的患病率明显高于正常血尿酸组（P〈0．01）；高尿酸血症与代谢综合征及其组分呈明显正相关。结论高尿酸血症与代谢综合征及其各组分密切相关，是构成代谢综合征的重要因素之一。

Objective To investigate the relationship between hyperuricemia and metabolic syndrome （MS） and its components. Methods A crosssectional survey with multiple - stages and random samplings was performed in adult persons aged over 18 who underwent health check up. There were 218 cases in hyperuricemia group and 224 cases in normal uric acid group. Then we observed blood glucose,triglyeeride, total cholesterol,uric acid,blood pressure and body weight index of the two groups. The prevalence rates of the metabolic syndrome and its components were calculated and analyzed in the two groups. Results The blood glucose,triglyceride,total cholesterol, LDL, blood pressure（SBP/DBP） , body weight index were significantly higher in hyperurieemia group than in normal uric acid group（ P 〈 0. 01 ）. The prevalence of MS,over weight/obesity, dyslipidoses, hypertension,hyperglycemia were significantly higher in hyperurieemia group than in normal uric acid group （ P 〈 0. 01 ）. Hyperuricemia was positively corretated with metabolic syndrome and its components. Conclusions Hyperuricemia is closely related to metabolic and its components. Hyperuricemia is one of the important factors for the metabolic syndrome population.