不同茵栀黄制剂辅助治疗新生儿黄疸比较

Comparative Study of Different Yinzhihuang Preparations in Treating Neonatal Jaundice

目的:比较茵栀黄颗粒、茵栀黄注射液辅助治疗新生儿高胆红素血症的疗效。方法:新生儿黄疸在常规治疗的基础上分为茵栀黄注射液组53例和茵栀黄颗粒组59例,测定患儿肝功能,观察两组治疗后总胆红素下降水平。结果:茵栀黄注射液组治疗3d及5d胆红素下降幅度分别为(105.7±48.4)μmol/L和(150.7±37.3)μmol/L,茵栀黄颗粒组治疗3d及5d胆红素下降幅度分别为(119.6±45.8)μmol/L和(139.6±35.6)μmol/L,两组比较差异无统计学意义(P>0.05)。结论:茵栀黄颗粒与茵栀黄注射剂辅助治疗新生儿黄疸疗效无明显差异,可以用口服制剂代替注射剂辅助治疗新生儿黄疸。

Objective： To investigate the effects of different preparation forms （Yinzhihuang granula and Yinzhihuang injection） in treatment of neonatal hyperbilirubinemia. Methods： The patients of neonatal hyperbilirubinemia were divided into two groups ： on base of the regular therapy, 53 cases were administered Yinzhihuang injection and 59 cases were administered Yinzhihuang granula. All the newborns were measured liver function. Changes of serum total bilirubin were observed after therapy to two groups. Results： Bilirubin of Yinzhihuang injection group decreased （ 105.7 ± 48.4） μmol/L and （ 150.7 ± 37.3 ） μmol/L in 3 and 5 days, respectively. It showed no difference with Yinzhihuang granula group [ （ 119.6 ±45.8 ）μ mol/L and （ 139.6 ±35.6） μmol/L] （ P 〉 0.05 ）. Conclusions ： The effect of Yinzhihuang granula and Yinzhihuang injection on the newborn jaundice had no obvious difference. Yinzhihuang granula can replace the later.