伊班膦酸钠治疗恶性肿瘤骨转移临床观察

Effect of Ibandronate in Treatment of Bone Metastasis of Malignant tumor

目的评价伊班膦酸钠治疗恶性肿瘤骨转移的疗效并观察其不良反应。方法47例恶性肿瘤骨转移患者给予伊班膦酸钠注射液4mg加入生理盐水500ml中,静脉滴注≥2h,4周1次,为1周期,3个周期后评价疗效。结果止痛显效9例,有效28例,无效10例,总有效率78.7%。体力状况改善显效3例,有效25例,无效19例,总有效率59.6%;骨转移病灶疗效CR 3例,PR 24例,总有效率为57.4%;高钙血症5例,显效3例,有效1例,有效率80.0%;不良反应主要为发热、骨关节痛、消化道反应等,发生率均较低,可以耐受。结论伊班膦酸治疗骨转移引起的疼痛疗效确切,而且能改善活动能力,骨转移病灶得到抑制,不良反应小,值得临床推广。

Objective To evaluate the curative effect of ibandronate and its adverse drug reaction （ADR） in patients with bone metastases from malignant tumor. Methods Total 47 patients diagnosed bone metastases from malignant tumor were given 4mg ibandronate in 500ml sodium chloride injection,iv,for more than 2h infusion, 1 time every 4 weeks for 12 weeks. Results The numbers of remarkable effect, effect and inefficacy after treatment were 9,28 and 10 cases respectively, the total analgesic rate was 78. 7%. The effective rate is 59. 6% on amelioration of physical capacity,the effective rate on bone metastases is 57.4 % ,and the eltective rate is 80. 0% on hypercalcinemia. The rate of ADR was relatively low,for example,fever,osteoarticular pain and nausea. Conclusion Ibandronate is effective and safe in treatment of pain,lyric lesion and hypercaleinemia caused by bone metastasis.