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金黄色葡萄球菌调节基因研究进展

Recent progress on regulator gene in Staphylococcus aureus
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摘要 金黄色葡萄球菌（金葡菌）感染开始多在皮肤或伤口，随后入血并侵犯组织。一旦金葡菌存在于组织内，便产生大量细菌成分和分泌物，其中包括细菌表面相关蛋白黏附素、酶、外毒素和囊膜多糖等基因表达产物，引起在组织内的侵袭、破坏和免疫反应，而上述众多细菌产物基因表达受金葡菌调节基因的调控表达。随着2001年金葡菌基因组测序工作的完成，通讨对基因组的分析，
作者 连建奇 白雪帆
机构地区 第四军医大学唐都医院全军感染病诊疗中心
出处 《中国感染控制杂志》 CAS 2009年第6期442-444,共3页 Chinese Journal of Infection Control
关键词 金黄色葡萄球菌 调节基因 mgrA 抗药性 微生物
分类号 R378.11 [医药卫生—病原生物学]
  • 相关文献

参考文献20

  • 1Kuroda M, Ohta T, Uchiyama I, et al. Whole genome sequencing of methicillin-resistant Staphylococcus aureus[J]. Lancet, 2001,357(9264) : 1225 - 1240.
  • 2Brunskill E W, Bayles K W. Identification of LytSR regulated genes from Staphylococcus aureus [J]. Bacteriol, 1996, 178 (19) :5810 - 5820.
  • 3Groicher K H, Firek B A, Fujimoto D F. The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance [J]. Bacteriol, 2000,182(7) : 1794- 1801.
  • 4Fournier B, Hooper D C. A new two-component regulatory system involved in adhesion, autolysis, and extraeellular proteolytic activity of Staphylococcusaureus [J]. Bacteriol,2000, 182(14) :3955 - 3964.
  • 5Ingavale S S, Van Wamel W, Cheung A L. Characterization of RAT, an autolysis regulator in Staphylococcus aureus [J]. Mol Mierobiol,2003,48(6) : 1451 - 1466.
  • 6Dubrac S, Boneca I G, Poupel O. New insights into the WalK/ WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus [J]. Bacteriol, 2007, 189 (22) :8257 - 8269. Epub 2007 Sep 7.
  • 7Kuroda M, Kuroda H, Oshima T,et al. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus [J]. Mol Microbiol,2003,49(3) :807 - 821.
  • 8连建奇,崔龙洙,平松启一.金黄色葡萄球菌调节基因mgrA高表达对苯唑西林耐药性的影响[J].中华微生物学和免疫学杂志,2006,26(7):603-609. 被引量：12
  • 9Truong-Bolduc Q C, Hooper D C. The transcriptional regulators NorO and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus [J]. Baeteriol, 2007,189 (8) : 2996 - 3005.
  • 10Neoh H M, Cui L, Yuzawa H,etal. Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-interrnediate resistance to vancomycin-intermediate resistance [J]. Antimicroh Agents Chemother,2008,52 (1) :45 - 53.

二级参考文献12

  • 1Luong TT,Newell SW,Lee CY.Mgr,a novel global regulator in Staphylococcus aureus.J Bac,2003,185(13):3703-3710.
  • 2Berger-Bachi B,Rohrer S.Factors influencing methicillin resistance in staphylococci.Arch Microbiol,2002,178:165-171.
  • 3Truong-Bolduc QC,Zhang X,Hopper DC.Characterization of NorR protein,a multifunctional regulator of norA expression in Staphylococcus aureus.J Bac,2003,185(10):3127-3138.
  • 4Ingavale SS,Wamel WV,Cheung AL.Characterization of RAT,an autolysis regulator in Staphylococcus aureus.Mol Microbiol,2003,48(6):1451-1466.
  • 5Kuroda M,Ohta T,Uchiyama I,et al,Whole genome sequencing of methicillin-resistant Staphylococcus aureus.Lancet,2001,357:1225-1240.
  • 6Kuroda M,Kuroda H,Oshima T,et al.Two-component system VraSR positively modulates the regulation of cell wall biosynthesis pathway in Staphylococcus aureus.Mol Microbiol,2003,49(3):807-821.
  • 7Cui L,Lian JQ,Neoh HM,et al.DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.Antimicrob Agents Chemother,2005,49(8):3404-3413.
  • 8连建奇 崔龙洙 黑田诚 等.Characterization of a novel regulator gene to increase bete—lactam resistance in S.aureus[J].日本细菌学杂志,2003,58(1):194-194.
  • 9Kaatz GW,Thyagarajan RV,Seo SM.Effect of promoter region mutations and mgrA overexpression on transcription of norA,which encodes a Staphylococcus aureus multidrug efflux transporter.Antimicrob Agents Chemother,2005,49(1):161-169.
  • 10Leski TA,Tomasz A.Role of penicillin-binding protein 2(PBP2) in the antibiotic susceptibility and cell wall cress-linking of Staphylococcus aureus:evidence for the cooperative functioning of PBP2,PBP4,and PBP2A.J Bacteriol,2005,187(5):1815-1824.

共引文献11

中国感染控制杂志
2009年 第6期

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