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组蛋白去乙酰化酶11与基因表达 被引量：2

Histone Deacetylases 11 and Gene Expression
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摘要 组蛋白去乙酰化酶11（histone deacetylases11，HDAC11）是最新发现的第Ⅳ类HDACs成员，是调节APC细胞IL-10转录的关键因子，对移植免疫耐受的产生起着负性作用。HDAC11还与中枢神经系统的发育有着紧密联系。拟通过对HDAC11在染色质中的作用靶点和作用机制进行综述，以期为移植免疫耐受的诱导和神经系统的功能的调节寻找到适宜的靶点。 HDAC11 （histone deacetylasesl 1 ） is newly found category IV member of HDACs, functioning as a key factor in regulating transcription of IL-10 of APC, and playing a negative role in transplanted immune tolerance. HDAC11 is also closely linked to the development of central nerv- ous system. This review summarizes the mechanism of HDAC11 in chromatin targeting, with the aim to explore appropriate targets related to induction of transplantation tolerance and regulation of nervous system function.
作者 赖星(综述) 董家刚(综述) 龚建平(审阅)
机构地区 重庆医科大学附属第二医院肝胆外科
出处 《医学分子生物学杂志》 CAS CSCD 2009年第6期538-541,共4页 Journal of Medical Molecular Biology
基金 资助项目：国家自然科学基金（No.30972888）
关键词 组蛋白去乙酰化酶11 白细胞介素.10 免疫耐受 HDACll IL-10 immune tolerance
分类号 R392.12 [医药卫生—免疫学]
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医学分子生物学杂志
2009年 第6期

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