mTOR信号通路与调节

mTOR Signaling Pathway and Regulation

哺乳动物雷帕霉素靶蛋白mTOR是一种非典型丝氨酸／苏氨酸蛋白激酶，可整合细胞外信号，磷酸化下游靶蛋白核糖体p70S6激酶，如S6K1及4E—BP1，影响转录与翻译，从而参与调控细胞生长、增殖等过程。近年来研究发现，调控mTOR通路可以干预某些疾病的病理过程。mTOR研究的新发现，可望为今后相关疾病的治疗提供新的靶点。

Mammalian target of rapamycin （mTOR） , an atypical Ser/Thr protein kinase, can integrate extracellular signals, and phosphorylates its downstream p70S6 kinases, such as S6K1 and 4E-BP1. Phosphorylation of S6KI and 4E-BPI is subsequently involved in regulation of tran- scription and translation, thereby modulating cell growth and proliferation. Recent studies have shown that some pathologic processes can be interfered through modulating mTOR pathways. Studies on mTOR signaling may provide insights into new targets for treatment of diseases related to roTOR signaling.