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全反式维甲酸对实验性动脉粥样硬化兔动脉平滑肌细胞骨桥蛋白表达的影响 被引量：7

Effect of alltransretinoic acid on expression of osteopontin in the artery wall of atherosclerotic rabbits
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摘要 目的探讨全反式维甲酸(ATRA)对动脉粥样硬化(AS)模型兔动脉骨桥蛋白(OPN)表达的影响。方法复制AS兔模型,采用免疫组化和Western blot分析主动脉OPN的表达。结果成功建立AS兔模型,高脂组兔主动脉OPN蛋白表达水平增加,经ATRA治疗后OPN蛋白表达下降,AS斑块减少。结论ATRA可能通过降低动脉OPN的表达抑制AS的形成。 Objective To study the effect of alhransretinoic acid on expression of osteopontin in the artery wall of atherosclerotic rabbits. Methods The rabbit model of atherosclerosis was induced by a high-cholesterol diet. The blood lipid levels were assayed in the serum of each group. OPN expression was detected by Western blot and im- munohistoehemical methods. Results The atherosclerosis model was established successfully. After fed with cho- lesterol for twelve weeks, the expression of OPN in the artery of atherosclerotic rabbits increased markedly, whereas the expression of OPN after fed with alhransretinoic acid for twelve weeks decreased compared with that of athcro- sclerotic rabbits. Conclusion It suggests that high expression of OPN in the artery might be closely correlated with the development of atherosclerosis. Alltransretinoic acid may play an important role in inhibiting the development of atherosclerosis by decreasing the expression of OPN.
作者 江志奎 朱华庆 程筱雯 肖林林 左莉 周青 汪渊
机构地区 安徽医科大学解放军临床学院 解放军第 安徽省部共建重要遗传病基因资源利用重点实验室
出处 《安徽医科大学学报》 CAS 北大核心 2009年第6期673-676,共4页 Acta Universitatis Medicinalis Anhui
基金 国家自然科学基金(编号:30971226) 安徽省自然科学基金(编号:090413091) 南京军区科技创新经费资助项目(编号:07M034-A) 解放军105医院科研课题基金(编号:2007001-A)
关键词 动脉粥样硬化 骨桥蛋白质 肌 平滑 血管 atherosclerosis osteopontin muscle, smooth, vascular
分类号 R332 [医药卫生—人体生理学] R322.121 [医药卫生—人体解剖和组织胚胎学]
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参考文献12

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共引文献7

同被引文献83

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引证文献7

二级引证文献15

安徽医科大学学报
2009年 第6期

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