浅表淋巴结转移癌组织C12蛋白芯片检测的意义

The clinical significance of C12 protein chip detective system in diagnosis of superficial lymph node metastasis carcinoma

目的探讨C12蛋白芯片检测在浅表淋巴结转移癌诊断中的意义。方法对已知细胞学诊断的浅表淋巴结组织细胞悬液进行C12检测,并同时对入选标本患者进行血C12检测,以病理诊断为最终标准,对以上两种结果进行对照分析。结果在35例浅表淋巴结转移癌中,细胞学的正确诊断率为57.1%(20/35),淋巴结组织细胞悬液C12检测阳性率为74.3%(26/35),两者相比差异有统计学意义(P<0.05);肿瘤组肿瘤标记物(TM)指标CA199、CEA、Beta-HCG、f-PSA、PSA、CA125、HGH、CA153在血和淋巴结组织细胞悬液中含量的比值具有统计学意义(P<0.05)。结论淋巴结组织细胞悬液C12检测对浅表淋巴结转移癌细胞学检查有一定的辅助诊断价值,但对淋巴结转移癌的组织学分类灵敏度不高。

Objective To investigate the value of detection of C12 protein chip in diagnosis of superficial lymph node metastasis carcinoma. Methods All superficial lymph node metastasis carcinoma patients were diagnosised firstly by cytological diagnosis ,the fine-needle aspiration specimens and serum samples of patients were determined with C12 muhi-tumor markers protein chip Detective System. The results were compared and analyzed with statistic method. Results In 35 cases of superficial lymph node metastasis carcinoma, the correct diagnosis rate of cytology was 57.1% （20/35）and C12 examination in lymph node cell suspension for testing positive rate was 74. 3% （26/ 35 ）, there was significant difference between them（ P 〈 0.05 ） ;The tumor markers（ TM ）CA199, CEA, Beta-HCG, f-PSA, PSA ,CA125, HGH, CA153 in blood of the tumor group had significant difference in the lymph node organiza- tion （ P 〈 0. 05 ）. Conclusion The examination of lymph node tissues cell suspensign C 12 have certain auxiliary diagnosis value in the cytological diagnosis of superficial lymph node metastasis carcinoma, but the sensitivity for histologic classification of lymph node metastasis carcinoma is not satisfactory.