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无氧间歇训练对大鼠骨骼肌、心肌、肝脏自由基代谢的影响 被引量:7

Effects of anaerobic interval training on free radical metabolism of skeletal muscle,myocardium and liver in rats
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摘要 背景:无氧间歇训练法是一种被广泛应用的重要训练方法,有关此训练对机体自由基代谢及其抗氧化酶活性影响的系统性研究较少。目的:观察无氧间歇训练对大鼠体内自由基代谢的影响。设计、时间及地点:随机对照动物实验,于2008-03/05在徐州师范大学运动生理实验室完成。材料:健康雄性SD大鼠32只,体质量230~270g,随机分为安静对照组,间歇训练对照组,间歇运动即刻组,间歇训练即刻组,每组8只。方法:安静对照组不进行训练,间歇训练对照组和间歇训练即刻组进行跑步运动,以坡度10°,速度26.8m/min运动1min,后以坡度为0,速度5m/min休息3min,每天连续20次不间断,5d/周,运动6周。间歇运动即刻组只在第6周最后一天进行一次运动。主要观察指标:6周运动结束后即刻麻醉下处死各组大鼠,测定其骨骼肌,心肌,肝脏超氧化物歧化化酶,谷胱甘肽过氧化物酶,过氧化氢酶,丙二醛。结果:①训练组运动后即刻各组织超氧化物歧化酶活性均显著高于间歇运动即刻组(P<0.05)。②间歇运动即刻组股四头肌、心肌谷胱甘肽过氧化物酶活性显著低于安静对照组(P<0.05),丙二醛含量显著高于安静对照组(P<0.05),股四头肌和肝脏过氧化氢酶活性显著高于安静对照组(P<0.05)。③间歇训练即刻组股四头肌、心肌谷胱甘肽过氧化物酶活性显著高于间歇运动即刻组(P<0.05),丙二醛含量明显低于间歇运动即刻组(P<0.05),股四头肌和心肌过氧化氢酶活性显著高于间歇运动即刻组(P<0.05)。结论:无氧间歇训练可以使机体抗氧化酶活性发生适应性变化,自由基清除能力增强。 BACKGROUND: As an import training method, anaerobic interval training is widely applied. However, systematically studies regarding the effects of this training on free radical metabolism and antioxidant system are few. OBJECTIVE: To study the effects of anaerobic interval training on free radical metabolism in rats. DESIGN, TIME AND SETTING: A randomized controlled animal experiment was performed at the laboratory of exercise physiology, Xuzhou Normal University from March to May 2008. MATERIALS: A total of 32 male SD rats, weighing 230 270 g, were randomly divided into four groups: sedentary control, interval training control, interval exercise immediate, and interval training immediate, with 8 animals in each group. METHODS: No training was performed in the sedentary control group. Rats in the interval training control and interval training immediate groups were run with speed of 26.8 m/min'for 1 minute at the gradient of 10°, then 5 m/min at gradient of 0°, followed by 3 minutes rest, this process was kept for successive 20 times per day, 5 days per week, for 6 weeks. Rats in the interval exercise immediate group were run once at the last day of the 6th week. MAIN OUTCOME MEASURES: Rats were sacrificed under anesthesia after 6 weeks, the super oxide dimutese (SOD), glutathione peroxidase (GPX), catalase (CAT) and malonaldehyde (MDA) contents in skeletal muscle, myocardium and liver were tested. RESULTS: ①After 6-week training, SOD activity in each tissues of the training groups were obviously greater than that of the interval exercise immediate group (P〈 0.05).②Compared to the sedentary control group, the GPX activity in quadriceps femoris and myocardium of the interval exercise immediate group was dramatically smaller (P 〈 0.05), but the MDA content was greater (P 〈 0.05), with higher CAT levels in quadriceps femoris and livers (P 〈 0.05). ③Compared to the interval exercise immediate group, the GPX activity of the interval training immediate group was notably higher in the quadriceps femoris and myocardium (P 〈 0.05), MDA level was lower, and the CAT levels increased remarkably in quadriceps femoris and myocardium (P 〈 0.05). CONCLUSION: Anaerobic interval training can induce adaptive change of antioxidant enzymes and enhance the ability of cleaning free radical.
作者 乔秀芳
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2009年第46期9129-9132,共4页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 中国矿业大学科研基金(0ZR4568)~~
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