抗骨质疏松药物临床应用的进展

Advances of anti-osteoporosis drugs in clinical application

骨质疏松症是一种常见的老年性疾病。近年来,随着对该病的病因及致病机制的深入研究,出现了多种抗骨质疏松药物,许多已在临床广泛应用。但是,在临床应用中发现,没有任何一种药物可以完全替代其他药物而取得满意的疗效,且每种药物都存在一定的缺陷。文章主要对抑制骨吸收,促进骨形成和骨矿化物3类药物进行探讨,分析它们的作用机制、临床应用研究新进展以及各自的不良反应,以指导临床选择针对性药物及联合用药,避免出现严重的不良反应,并寻找进一步研究方向。

Osteoporosis is a common disease in the elderly. As studies on its causation and pathogenic mechanism deepened in recent years, there appeared many anti-osteoporotics and many of them had been widely used in clinic. However, none of them was found to be able to completely replace other drugs to achieve satisfactory effect in clinical applications. They all have certain defects. In this paper, three types of drugs including bone resorption inhibitors, bone mineralizers and bone formation accelerators were analyzed in terms of their mechanisms of action, advances in clinical application as well as their side effects, so as to guide the clinical choice and combination of drugs targeted to avoid serious side effects and to seek for the direction of further study.