基于氢核磁共振-主成分分析建立洁尔阴洗液质量控制的研究

Based on ^1H-NMR-PCA to establish a quality control method of Jie-Er-Yin Lotion

目的从全面的角度出发，建立一种基于氢核磁共振主成分分析的洁尔阴洗液质量控制新方法。方法将洁尔阴洗液与不同的缺味制剂（缺蛇床子、缺黄柏、缺苦参、缺辅料制剂或缺全药材制剂）用相同的方法处理后．以^1H—NMR技术测定样品的全化学成分信息，然后对图谱进行数据提取和分析。结果所得的数据通过模式识别法中的主成分分析（PCA），在得分散点图中实现了对不同种类的制剂的区分。结论氢核磁共振-主成分分析是一种有效的全成分分析法，能够更全顽地体现药品质量情况，并且操作简便，因此可作为洁尔阴洗液质量控制的手段之一。

Objective To establish a new method of quality control for Jie-Er-Yin Lotion. Methods Jie-Er-Yin Lotion and different kinds of agents （without Fructus Cnidii, Cortex Phellodendri Chinensis, Radix Sophorae Flavescentis, excipient agent or all medicinal material agents） were treated with the same approach, then using ^1H-NMR to get all of the chemical component information of the samples and analyze the data from the spectra. Results Analyzing the data with principal component analysis （PCA） by model recognition, the different agents can be distinguished in the scattered plots. Conclusion The ^1H-NMR-PCA is an useful method to identify Jie-Er-Yin Lotion from other preparations and can be used for the quality control of Chinese prepared medicines by simple operation.