药用甲苯胺蓝合成新工艺及分析新方法

A New Method of Synthesis and Analysis of High quality Toluidine Blue o for Medical Uses

近些年来，甲苯胺蓝作为噻嗪类染料在医药、生化方面的应用日益广泛，报道甚多〔１～６〕．有关其合成的报道虽多，但真正可用于生产的工艺很少，原因是以邻甲苯胺为最后环化的原料，在强氧化剂条件上，反应复杂，副产物很多．到目前为止，市场上的甲苯胺蓝只能作为染料，...

High quality toluidine blue o for medical uses was produced on a large scale with a new method starting from dimethyl aniline in one pot.The product was analyzed by HPLC and the position isomer of the methyl group in the molecule was found for the first time.The factors which affected the quality of the product were discussed.