5-酰基-3 H-1,2-二氢-1-吡咯里嗪酮衍生物的合成

Synthesis of 3 H 1,2 Dihydro 1 Pyrrolizinone Derivatives

曾报道了一些３Ｈ１，２二氢１吡咯里嗪酮（下称吡里酮，Ｉ）类化合物的合成〔１〕．药理试验表明〔１〕，许多５酰基吡里酮衍生物具有较强的解热镇痛和抗炎作用．为进一步研究该类化合物的结构和抗炎镇痛作用的关系，设计合成了１０个未见文献报道的５酰基吡...

Some compounds of 3 H 1,2 dihydro 1 pyrrolizinone exhibit anti inflammatory and analgesic activities.Ten new 5 acy1 3 H 1,2 dihydro 1 pyrrolizinone derivatives were designed and synthesized by the Friedel Crafts reaction and Claisen Schmidt reaction respectively in this paper.