碘重排法合成酮基布洛芬

Synthesis of Ketoprofen via Rearrangement Using Iodine as the Catalyst

以苯丙酮为原料，经溴化、氰化、水解、ＦｒｉｅｄｅｌＣｒａｆｔｓ反应，制得３丙酰基二苯酮（６）．化合物（６）在原甲酸三乙酯中，用碘使之重排，经水解即得酮基布洛芬，总收率为２８％．

An efficient preparation of ketoprofen was described.Propiophenone was used as the material via bromination ,cyanation ,hydrolysis,the Friedel Crafts′ reaction to give 3 propionylbenzophenone,which was converted to ketoprofen by rearrangement with iodine.The overall yield was 28% from propiophenone.