肝硬化并发自发性细菌性腹膜炎患者肿瘤坏死因子α的检测及意义

Levels and Significance of TNF-αin Cirrhotic Patients with Spontaneous Bacterial Peritonitis

为探讨肿瘤坏死因子。在肝炎后肝硬化并发自发性细菌性腹膜炎（SBP）中的变化及临床意义，采用双抗体夹心法酶联免疫吸附试验，检测肝硬化腹水患者、肝硬化并发SBP患者及癌性腹水患者血清或腹水中肿瘤坏死因子α水平。结果显示：肝硬化并发SBP及癌性腹水患者肿瘤坏死因子α水平明显升高，与正常对照组比较均有明显差异（P＜0．05）；肝硬化并发SBP患者腹水中肿瘤坏死因子α较肝硬化腹水患者明显升高（P＜0．05）。经抗生素治疗后，肝硬化并发SBP患者血清或腹水中肿瘤坏死因子α显著下降（P＜0．05）。提示：检测血清或腹水中肿瘤坏死因子α水平可反映机体的感染状况、预测治疗的效果与预后。

Objective: to investigate levels and significance of TNFa in cirrhotic patients with spontaneous bacterial peritonitis (SBP). Enzyme linked immunosorbent assay was used to meassure levels of TNF-α in serum and ascites of cirrhotic patients、Cirrhotic with SBP patients and cancer patients. Levels of TNF-α in patients with SBP and can cerous ascites were higher than that of cirrhotic patients and normal controls (P<0.05). After therapy with antihiotics, levels of TNFQ in SBP patients droped significant ly (P < 0. 05). TNF-αmay be used as markers of therapeutic effect and prognosis of bacterial infection in cirrhotic patients.