肺癌合并静脉血栓栓塞症15例临床分析

Venous thromboembolism in non-small-cell lung cancer patients:Report of 15 cases

目的静脉血栓栓塞症(VTE)是恶性肿瘤(包括肺癌)常见并发症及主要死亡原因之一。本研究结合文献分析住院肺癌患者VTE的临床特征及治疗。方法回顾分析我院肺癌病区2007年9月～2008年10月间260例肺癌患者中发生的15例血栓栓塞症患者临床表现、诊断方法、治疗及转归。结果本组15例患者中12例的发生与静脉置管相关。肺栓塞通过增强CT扫描确诊,其余静脉血栓通过超声确诊。经过皮下注射低分子肝素治疗绝大多数患者的血栓完全消失。结论血栓栓塞症是肺癌的主要并发症之一,及时的确诊和包括低分子肝素为主的治疗可使绝大多数患者的血栓得到完全消失。

Objective Venous thromboembolism （VTE） is a major complication of cancer and one of the leading causes of death in patients with cancer. We therefore assessed the incidence and therapeutic options of VTE in Chinese lung cancer patients. Methods We retrospectively evaluated the charts of 260 patients with lung cancer at our ward between September 2007 and October 2008 and found 15 patients with VTE. We analyzed the clinical manifestations, diagnostic methods, treatment options, and outcomes of these patients. Results Of 15 patients, the VTE of 12 patients were contributed by central venous catheters. One patient with PE was diagnosed by CT scan, and others with venous thrombosis were confirmed by ultrasound. The low-molecular-weight heparins （LMWHs） were administered to these patients, and satisfactory results were obtained. Conclusion VTE should be carefully detected in patients with lung cancer include early detection and treatment. LMWHs have demonstrated optimistic efficacy and safety profiles.