尿胰蛋白酶原-2和肿瘤坏死因子-α在急性胰腺炎诊断及早期严重度评估中的意义

The significance of urinary trypsinogen-2 and tumor necrosis factor-α to diagnose and assess the severity of acute pancreatitis in the early stages

目的探讨尿胰蛋白酶原-2(Tps-2)和肿瘤坏死因子-α(TNF-α)在急性胰腺炎(AP)诊断及早期严重度评估中的价值。方法选取AP患者81例[60例重症患者和21例轻症患者],非急性胰腺炎患者40例作为对照。在入院后1h、24h、3d留取尿液做Tps-2测试,SAP组和MAP组在入院后1h、24h、3d、抽血测试TNF-α,并对结果进行对照分析。结果胰腺炎组81例中有77例Tps-2结果阳性,而对照组40例中仅3例阳性;SAP组和MAP组在入院后24h、3d检测TNF-α的水平比较差异有统计学意义(P<0.05)。结论尿胰蛋白酶原-2可以很好诊断AP,肿瘤坏死因子-α动态检测可作为AP患者病情变化的指标,对AP早期严重度具有良好的预测作用。

Objective To explore the value of the urinary trypsinogen-2 （Tps-2） to diagnose acute pancreatitis （AP） and tumor necrosis factor-α （TNF-α） to assess the severity of acute pancreatitis in the early stages. Methods We chosen 81 cases of acute pancreatitis （60 cases of severe patients and 21 cases of mild patients） in AP group and 40 cases of patients with non-acute pancreatitis as a control. Tps-2 urine at post-admission 1 h, 24 h, 3 d and TNF-α of SAP and MAP group at post-admission 1 h, 24 h, 3 d, were dedicated. Then we analyzed and contrasted the results. Results 77 cases were positive of Tps-2 from 81 eases of pancreatitis and only three cases were positive in 40 cases of the control group. The difference of the level of TNF-α between SAP and MAP groups detected at post-admission 24 h, 3 d were statistically significant （ P 〈 0.05 ）. Conclusions Urinary Trypsinogen -2 to diagnose AP can be a very good method, tumor necrosis factor-α to detected dynamically AP can be used as indicators of changes in AP,and it has a good role to early severity prediction of AP.