0．45％氯化钠溶液与灭菌注射用水在机械通气患者气道湿化中的对照研究

Control study in 0.45% sodium chloride solution and sterile water for injection in airway humidifi- cation of patients with mechanical ventilation

目的观察两种不同湿化液在建立人工气道机械通气患者气道湿化中的作用。方法将我院2009年1-4月心脏外科接受心脏手术治疗后行机械通气的患者40例，利用随机数字表随机分为A组和B组各20例，A组给予0．45％氯化钠溶液100ml加沐舒坦15mg气道湿化液，B组给予灭菌注射用水100ml加沐舒坦15mg作为气道湿化液，观察2组患者吸出痰液的量、颜色、黏稠度、患者的体温、肺部的听诊以及x线胸片情况。结果机械通气后4、8、16、24h及l～2、3～5、6．7d2组患者痰液的量、颜色、黏稠度、患者的体温以及x线胸片情况比较无显著差异，2组患者机械通气后4、16、24h，1-2、3-5、6-7d患者的肺部听诊隋况无显著差异，机械通气后8h的肺部的听诊情况B组优于A组。结论没有足够的依据认为0．45％氯化钠溶液100ml加沐舒坦15mg和灭菌注射用水100ml加沐舒坦15mg作为气道湿化液在机械通气患者气道湿化中的作用效果不同。

Objective To observe the two different wetting fluid in airway humidification of pa- tients with mechanical ventilation. Methods 40 patients with mechanical ventilation after cardiac surgery in our hospital from January to April, 2009, were divided randomly into group A and group B, group A was given 0.45% sodium chloride solution lO0ml plus ambroxol 15mg as airway humidification fluid, group B was given sterile water for injeetionl00 ml plus ambroxol 15rag as airway humidification liquid. The amount of sputum aspiration, color, viscosity, the body temperature of patients, the lungs auscultation and chest X-ray were observed. Results No statistical difference was seen in sputum volume, color, viscosity, the body temperature of patients, lungs auscultation as well as chest X ray after mechanical ventilation for 4 hours, 8 hours,16 hours, 24 hours, 1N2 d, 3N5 d, 6~7 d. No statistical differ- ence was also seen in auscultation of the lung after mechanical ventilation for 4 hours, 16 hours, 24 hours, 1-2 d, 3-5 d, 6~7 d. But auscultation of the lung in group B was better than that of group A after mechanical ventilation for 8 hours. Conclusions No sufficient fact can prove that different effect ex- ists between 100 ml 0.45% sodium chloride solution plus ambroxol 15rag and 100 ml sterile water for injection plus ambroxol 15mg as airway humidification fluid during mechanical ventilation.