螯合剂对犬心血管系统的急性效应研究

Effect of chelating agents on cardiovascular system in dogs

本文研究了4种对放射性核素钍、锶有较好促排效果的螯合剂对犬心血管系统的影响。结果表明，螯合剂静注给药剂量100mg／kg（约为人用剂量的5倍）时，对犬心率、血压、EKG、血钙、血钾有不同程度的影响，其中S186、8102、8307的影响较小，仅8102使血钙一过性明显下降，8307使犬血压瞬时降低；7603毒性较大，静注即刻血压急骤下降，心率明显减慢，EKG出现S—T段显著压低、T波平坦，2～3分后T波倒置，多发性室性早搏，呼吸停止。降低静注剂量为50mg／kg，亦出现心率、血压、EKG瞬时明显变化，其毒性作用可能主要与血钙骤降有关。肌注以上螯合剂100mg／kg，对犬血管系统、血钙无明显影响。

The effects of intravenously or intramuscularly injected chelating agents-S186, 8102,8307, 7603 on the cardiovascular system were examined pharmacologically in dogs. When injected intravenously at 100mg/kg dose (five times the amount of human dose), four chenting agents exert an influence in varying degrees on the blood pressure, EKG and the concentration of serum calcium in dogs. The toxicity of S186, 8102, 8307 were lower. 8102 made the concentration of serum calcium decreased significantly 5 min after the injection and return to normal 30 min later. 8307 caused the blood pressure intantaneously dropped. The toxicity of 7603 was higher. When it, at 100mg/kg dose, was injected intravenously,the sudden drop of the blood pressure and the heart failure showing the decreases of the heart rates, predominant depression of S-T segment and flatness or inversion of T wave were observed and respiration ceased 2～3 min after injection. Instantaneous and significant changes were also observed in the heart rates, blood pressure and EKG at 50mg/kg dose. On the other hand, no untoward findings were seen in the cardiovascular system by intramuscularly injected chelating agents in dogs.