山楂提取物防治高脂血症实验研究

Experimental study of Crateagus pinnatifida on hyperlipidemia prevention and treation

目的观察山楂提取物对高脂血症大鼠的预防性降脂和治疗性降脂作用。方法采用灌胃高脂乳剂建立大鼠高脂血症模型,测定不同剂量山楂提取物对高脂血症大鼠的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的影响。结果山楂提取物中剂量(0.15mg/kg·d)、高剂量(0.3mg/kg·d)均可使高脂血症大鼠的TC,TG和LDL-C显著降低(P<0.05,P<0.01)。结论山楂提取物对高血脂症具有预防和治疗作用。

Objective To investigate the effect of Crateagus pinnatifida on hyperlipidemia prevention and treation. Methods The hyperlipidemia model in rats was set up by feeding with high cholesterol diet. After having been treated for one month, blood-fat levels （ TC, TG, LDL-C and HDL-C） in serum were measured ; the rats were sacrificed and the aortas were collected for pathological changes. The levels of TNF-α, IL-6 and ICAM- 1 in serum were also measured by ELISA. Results Crateagus pinnatifida could significantly decrease the contents of serum TC, TG and LDL-C, and reduce the score of pathological changes of the hyperlipidemia, while the level of HDL-C was increased as compared with that of model group （P 〈 0.05 or P 〈 0. 01 ）. Conclusion The results indicate that Crateagns pinnatifida can inhibit experimental hyperlipidemia, and prevent the formation of hyperlipidemia.