广西汉族老年缺血性脑卒中患者胱硫醚β-合酶（CBS）基因C572T突变频率

Mutation Frequency of Cystathionine β-Synthase Gene C572T in the Elderly Patients with Ischemic Stroke in Han Population of Guangxi

目的初步探讨同型半胱氨酸（Hey）代谢相关酶胱硫醚β-合酶（CBS）基因C572T基因突变与广西汉族老年缺血性脑卒中发病的相关性。方法采用等位基因特并性扩增技术检测75例广西汉族老年缺血性脑卒中患者和50例正常健康体检者（对照组）CBS基因C572T基因型。结果老年缺血性脑卒中组CBS基因C572TT／T，C／T和C／C基因型频率分别为6．67％，82．67％和10．67％，对照组分别为4％，86％和10oA；老年缺血性脑卒中组C等位基因频率为52％，T等位基因频率为48％，对照组分别为53％扣47％，基因型频率、等位基因频率，两组差异无统计学意义（Χ^2=0．43，Χ^2=0．02，P〉0．05）。结论CBSC572T基因突变与广西汉族老年缺血性脑卒中发病无明显相关性，其基因突变可能不足于构成广西汉族老年缺血性脑卒中发病的独立遗传危险因素。

Objective To study the effect of gene mutation of cystathionine beta-synthase in elderly patients with ischemic stroke in han population of Guangxi. Methods 75 elderly patients with ischemic stroke and 50 controls were recruited G572T genotypes were detected by the technique of allele-specific amplification polymerase chain. Results The frequency of T/T was accounted for 6.67%, C/T for 82.67% ,C/C for 10. 67% among the patients;4% ,86% ,10% ,respectively a- mong the control subjects. The frequency of T alleles was not significant difference between patients and normal controls （Χ^2=0.43,Χ^2=0.02,P〉0.05）.Conclusion There was not significant correlation between C572T and elderly patients with ischemic stroke in Han population of Guangxi,CBS C572T may not be independent risk factor for elderly patients with ischemic stroke in Guangxi.