西安地区2004-2008年社区获得性志贺菌感染率及其耐药性分析

Analysis of Community-acquired Shigella Infection and Drug Resistance in Xi＇an Area 2004~2008

目的了解西安地区社区获得性志贺菌血清型分布及耐药性，为西安地区社区获得性志贺菌的经验治疗提供客观依据。方法收集2004～2008年西安地区三家三级甲等医院标本进行鉴定、血清学分型和药敏试验。结果4733份送检标本中，共检出71株志贺菌，阳性率为1．5％（71／4733）；其中66株为福氏志贺菌（占93％），4株为宋民志贺菌（占5．6％），1株为痢疾志贺菌（占1．4％）。在福氏志贺菌中，F2a占71．2％（47／66），F2b占1．5％（1／66），F4c占27．3％（18／66），未检出鲍氏志贺菌。2004-2008年期间复方新诺明耐药率最高（86．7％～100％），其次为氨苄青霉素（50％～90％），左氧氟沙星耐药率最低（0％～10％）。结论福氏志贺菌是西安地区细菌性痢疾的主要病原菌，对目前常用的抗菌药物已表现出一定的耐药性，应引起高度重视。

Objective To investigate the Xi＇an area community-acquired Shigella serotype distribution and drug resistance, provide an objective basis treatment for the Xi＇an area community-acquired experience Shigella. Methods Collected samples from three hospital of third grade first-class 2004-2008 year. Bacterial identification by VITEK 32,Serotype by serological methods and drug sensitivity test. Results 4 733 samples were submitted,71 were detected Shigella,the positive rate was 1.5% （71/4 733）. 66 for Shigella （93%） ,4 for the Song of Shigella （5.6%） ,1 for Shigella dysentery （1.4%）. In Shigella ,F2a accounted for 71.2% （47/66）,F2b accounted for 1.5%（1/66）,F4c accounted for 27.3%（18/66）,not detected Shigella boydii. The highest rate of sulfamethoxazole resistance （86.7%- 100%）,followed by ampicillin （50%- 90% ） ,the lowest rate of LEV （0 % - 10%）. Conclusion S. flescneri is the main pathogen for bacillary dysentery in the region and antimicrobial agents commonly used has shown certain degree resistance. This should pay high degree attention.