女性尿毒症患者输血、妊娠和再次移植与群体反应性抗体（PRA）的关系

Relationship between Transfusion, Pregnancy, Second Transplantation and PRA in Female Uremia Patients

目的探讨女性尿毒症患者输血、妊娠和再次移植与群体反应性抗体（PRA）产生的关系，为肾移植手术的准备和预测移植肾排斥提供参考。方法采用HLA—Ⅰ类、Ⅱ类混合抗原板，检测154例女性尿毒症患者PRA，年龄21～68岁。结果在154例女性尿毒症患者中，单纯输血的13例，PRA阳性患者有2例；单纯妊娠的55例，PRA阳性患者有6例；输血加妊娠的患者33例，PRA阳性患者有9例；再次移植患者53例，PRA阳性患者有29例。结论单纯输血、单纯妊娠扣输血加妊娠导致PRA生成的几率较低，三者之间差异无统计学显著性意义。而再次移植患者与单纯输血、单纯妊娠扣输血加妊娠之间PRA生成的几率差异有统计学显著性意义。

Objective To investigate the relationship between transfusion,pregnancy,second transplantation and panel reactive antibody （PRA） in female uremia patients for reference of forecasting renal rejection and get ready for following transplant. Methods 154 female uremia patients were tested for PRA before transplantation. Age range 21-68. Results 13 of the 154 patients received transfusion before transplantation,2 of the 13 patients showed PRA positive. 55 of the 144 patients were pregnancy,in which there were 6 patients showed PRA positive. 33 of the 144 patients were both transfused and pregnancy,9 of the 33 patients showed PRA positive. 53 patients who received second transplantation,29 out of the 53 patients showed PRA positive. Conclusion The incidence of PRA induced by transfusion,pregnancy or transfusion and pregnancy was low,there was no significance differe：.ce. However,patients who received second transplantation had more incidence to produce PRA than transfusion,pregnancy or transfusion and pregnancy patients,the difference was significant between them.