摘要
ＡＤＡ－ＬａｃＺ融合基因经直接注射导入大鼠骨骼肌内，用Ｘ－ｇａｌ和ＡＤＡ组化染色方法检测的结果表明：在大鼠骨骼肌细胞中，可检测到由ｐＦＰ表达的ＡＤＡ和β－ｇａｌ活性。这提示有望探索出一条对某些遗传性疾病、肿瘤及其它多种疾病导入外源基因实施基因治疗的便捷。
ADA LacZ fusion gene was directly injected into the skeleton muscle of Wistar rat. The expression
products were detected by immunohistochemical staining. The results showed that a biofunctional
protein which possesses ADA and β galactosidase activites was encoded. It suggested that long
sequence gene could be expressed in vivo by direct injection.
出处
《中国优生与遗传杂志》
1998年第6期18-19,共2页
Chinese Journal of Birth Health & Heredity
基金
卫生部和湖北省卫生厅科研基金
