β-七叶皂甙钠对急性脑梗死患者血清hs-CRP的影响

Effect of sodium β-aescinate on high sensitivity c-reactive protein of the patients with acute cerebral infarction

目的通过观察急性脑梗死患者使用β-七叶皂甙钠前后血清高敏感C-反应蛋白的水平的变化,探讨β-七叶皂甙钠在急性脑梗死治疗中的抗炎作用。方法选择100例急性脑梗死患者,患者随机分为治疗组和对照组各50例,治疗组给予β-七叶皂甙钠20mg/d静滴,其他用药同对照组,对照组每天静脉应用丹参注射液、胞二液胆碱等药物,应用放射免疫比浊法检测治疗前、治疗后3d、7d、14d的血清hs-CRP水平变化,并进行神经功能缺损标准评分(CSS)。结果两组患者在脑梗死后3天hs-CRP水平最高,随后渐降低,治疗后7d治疗组hs-CRP水平明显低于对照组,差异有显著性(P<0.05)。14d治疗组神经功能缺损明显优于对照组,差异有极显著性(P<0.01)。结论β-七叶皂甙钠在急性脑梗死患者治疗中可以降低患者血清hs-CRP水平,有利于减轻炎症反应,改善脑梗死缺血缺氧和缺损的神经功能。

Objective To investigate the relationship between sodium aescinate and serum high sensitity C-reactive protein （hs-CRP） in the patients with acute cerebral infarction.Methods 100 patients with cerebral farction were divided into two groups randomly.In the treatment group（n=50）,the patientnts were given Sodium β-Aescinate 20mg/d by IV instillation qd.Conventional treatment for patients of both groups was the same except for Sodium β-Aescinate.Patients of the control group were given Danshen Injection,CDPC by IV instillation qd.The course of the treatment in the two groups lasted for 14 days.The neurologic impairment scores were noted down and concentrations of soluble hs-CRP before the treatment and on the 3rd day,7th day and the 14th d after the treatment.The level of serum hs-CRP was measured by scatter immune turbidity method.Results hs-CRP reached the highest level on the 3rd day and then decreased slowly.The decline in serum level of hs-CRP on the 7th day ＇after the treatment was more striking in patients of the treatment group than that of the control group （P 〈 0.05）.The decline of he neurolngic impairment scores on the 14th day after the treatment was more striking in the patients of the treatment group than that of the control group （P 〈 0.01）. Conclusions Sodium β-Aescinate can decrease the density of the serum hs-CRP and the inflammatory reaction.It meas that Sodium β-Aescinate can play an important roel in protecting brain cells and blood ressel endothelial cells,and decrease the inflammatory redion.