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人防御素分子生物学研究进展及其应用 被引量：2

Advances in the Research and Application of Human Defensins
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摘要 人防御素(human defensins)是一类内源性阳离子抗微生物肽,在天然免疫防御中起重要作用,也能增强继承性免疫应答。它具有强烈的广谱抗微生物活性,并且不易对微生物产生耐药性。对人防御素的分子生物学特性方面的研究进展作一综述,重点在于比较和探讨其结构的异同,并对其应用和发展的前景进行展望。 Human defensins as a family of endogenous cationic antimicrobial peptides,play an important role both in innate and adaptive defense systems. They exhibit a broad range of intensive antimicrobial activities and do not bear drug resistance against microorganism easily. An overview of the mollecular biological characteristics of human defensins with some emphasis on comparing and discussing the differences of their constructions was presented. The prospects for application and development of human defensins were also dicussed.
作者 高金湖 唐存多 邬敏辰
机构地区 江南大学医药学院
出处 《生物技术通报》 CAS CSCD 北大核心 2009年第12期30-36,共7页 Biotechnology Bulletin
关键词 人防御素 抗菌肽 分子生物学特性 Human defensins Antimicrobial peptides Mollecular biological characteristics
分类号 Q51 [生物学—生物化学]
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参考文献35

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共引文献6

同被引文献22

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生物技术通报
2009年 第12期

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