期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

食管鳞癌组织中p34^(cdc2)的表达变化及意义 被引量：1

Expression and significane of p34^(cdc2) in esophageal squamous cell carcinoma
下载PDF
导出
摘要 目的观察人食管鳞癌组织中细胞分裂周期蛋白p34cdc2的表达,并探讨其临床意义。方法利用组织芯片技术结合免疫组化及蛋白免疫印迹法检测138例食管癌患者肿瘤组织和配对正常食管黏膜组织中的p34cdc2蛋白。结果p34cdc2在食管鳞癌组织的表达明显高于配对正常黏膜组织,P<0.01。p34cdc2表达与食管鳞癌临床分期、淋巴结转移有关(P均<0.05),与分化程度和肿瘤浸润深度等无关(P均>0.05)。结论食管癌组织中p34cdc2表达升高。p34cdc2可促进食管癌的发生与发展。 Objective To investigate the expression and significance of p34^cdc2 in human esophageal squamous cell carcinoma（ESSCC）. Methods The expression of p34^cdc2 in human esophageal cancer tissues（ n = 138） and corresponding normal mucosa were determined by tissue microarray（TMA） , immunohistochemical（IHC） method and Western blot analysis. Results The difference was statistically significant between the expression of p34^cdc2 in cancer tissues and their corresponding normal mucosas （P 〈 0.01 ）. Expression of p34^cdc2 was statistically relative with clinical stages and lymphatic metastasis （ P 〈 0.05 ）, but not relative with histological grades, depth of invasion （ P 〉 0.05 ）. Conclusion p34^cdc2 over express in ESSCC. It may promote the occurrence and development of ESSCC.
作者 华丛书 于在诚 刘芝华 骆爱萍
机构地区 安徽医科大学第一附属医院 中国医学科学院肿瘤研究所
出处 《山东医药》 CAS 北大核心 2009年第38期4-6,共3页 Shandong Medical Journal
基金 国家自然科学基金资助项目(2004CB518604)
关键词 食管肿瘤 食管鳞癌 p34cdc2蛋白 esophageal neoplasm esophageal squamous cell carcinoma p34^cdc2 protein
分类号 R735.1 [医药卫生—肿瘤] R394.3 [医药卫生—医学遗传学]
  • 相关文献

参考文献11

  • 1Burkhardt M, Mayordomo E, Winzer KJ, et al. Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer[J]. J Clin Pathol,2006,59:403-409.
  • 2Solomon MJ. The function(s) of CAK. The p34^cdc2-activating kinase [J]. Trends Biochem Sci, 1994,19 ( 11 ) :496.
  • 3Solomon M J, Lee T, Kirschner MW. Role of phosphorylation in activation: identification of an activating kinase [J]. Mol Biol Cell, 1992,3(8) :13.
  • 4Charrier-Savoumin FB, Chateau MT, Gire V, et al. p21 -mediated nuclear retention of eyclinBI/CDK1 in response to genotoxie stress [ J ]. Mol Biol Cell,2004,15(9) :3965-3976.
  • 5Yasui W, Ayhan A, Kitadai Y, et al. Increased expression of p34^cdc2 and its kinase activity in human gastric and colonic carcinomas[J]. Int J Cancer, 1993,53 (1) :36-41.
  • 6Ito Y,Taieda T,Wakasa K,et al. Expression of the G2-M modulators in pancreatic adenocarcinoma[J]. Pancrewtology,2002,2 (2) : 138-145.
  • 7Kawamoto H, Koizumi H, Uchikoshi T. Expression of the G2-M checkpoint regulators cyclin Bland cdc2 in nonmalignant and malignant human breast lesions immunocyto chemica land quantitative image analyses[J]. Am J Pathol, 1997,150 ( 1 ) : 15-23.
  • 8Hansel DE,Huang RC,Huang RC,et al. Cdc2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target EJ3[J]. Am J Surg Pathol,2005,29(8) :390-399.
  • 9Hermeking H, Benzinger A. 14-3-3 proteins in cell cycle regulation [J]. Semin Cancer Biol,2006,16(3) :183-192.
  • 10Hunter T,Pines J. Cyclins and cancer Ⅱ cyclin D and CDK Inhibitors come and age[ J]. Cell, 1994 ,79 (4) :573-582.

同被引文献19

  • 1翟德忠,黄强,朱卿,董军,霍红梅,兰青.组织芯片/免疫组化检测CDC2/CyclinB1在胶质瘤中的联合表达及意义[J].中国肿瘤临床,2007,34(11):604-607. 被引量：7
  • 2XU N,CHANG D C.Different thresholds of MPF inactivation are responsible for controlling differentmitotic events in mammalian cell division[J].Cell Cycle,2007,6(13):1639-1645.
  • 3KIM D H.Prognostic implications of cyclin B1,p34cdc2,p27(Kip1) and p53 expression in gastric cancer[J].Yonsei Med J,2007,48(4):694-700.
  • 4CHANG J T,WANG H M,CHANG K W,et al.Identification of differentially expressed genes in oral squamous cell carcinoma(OSCC):overexpression of NPM,CDK1 and NDRG1 and underexpression of CHES1[J].Int J Cancer,2005,114(6):942-949.
  • 5SOLOMON M J.The function(s) of CAK,the p34cdc2-activating kinase[J].Trends Biochem Sci,1994,19(11):496-500.
  • 6SOLOMON M J,LEE T,KIRSCHNER M W.Role of phosphorylation in activation:identification of an activating kinase[J].Mol Biol Cell,1992,3(8):13-27.
  • 7CHARRIER SAVOUMIN F B,CHATEAU M T,GIRE V,et al.p21-mediated nu-clear retention ofcyclinBI/CDK1 in response to genotoxic stress[J].Mol Biol Cell,2004,15(9):3965-3976.
  • 8HERMEKING H,BENZINGER A.14-3-3 proteins in cell cycle regulation[J].Semin Cancer Biol,2006,16(3):183-192.
  • 9HANSEL D E,HUANG R C,HUANG R C,et al.Cdc2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progressionmarker and potential novel drug target[J].Am J Surg Pathol,2005,29(8):390-399.
  • 10KIM S J,NAKAYAMA S,MIYOSHI Y,et al.Determination of the specific activity of CDK1 and CDK2 as a novel prognostic indicator for early breast cancer[J].Ann Oncol,2008,19(1):68-72.

引证文献1

二级引证文献4

山东医药
2009年 第38期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部