吐温-80及其助溶荆芥挥发油和丹皮酚的超滤适用性研究

Research on Applicability of Tween-80 and It Solubilizing Schizonepeta Volatile Oil and Paeonol of Ultrafiltration

目的研究吐温-80及其助溶荆芥挥发油和丹皮酚的超滤适用性。方法以压力、温度、浓度及膜孔径四因素进行正交设计,成分含量为检测指标,测定超滤前后药液成分的浓度,计算透过率,观察吐温-80及其助溶荆芥挥发油和丹皮酚溶液超滤前后的含量变化。结果四因素对吐温-80有一定影响,自身浓度的影响最大,且具有统计学意义(P<0.01);在超滤过程中,丹皮酚、荆芥挥发油透过率均比较低,四因素经方差分析均无统计学意义(P>0.05)。结论吐温-80助溶荆芥挥发油和丹皮酚进行超滤的适用性较差。

Objective To study the applicability of ultrafiltration of tween-80 and it solubilizing schizonepeta volatile oil and paeonol of ultraffltration. Method Taking components content as index, temperature, pressure, concentration and membrane pore size were selected as factors for orthogonal design method. The concentration was determinated in medical solution before and after ultrafiltration, and the transmittance rate （TS） was calculated to observe the content variation of tween-80 and it solubilizing solution. Results The four factors had markedly effect on TS of tween-80, concentration was statistically significant （P〈0.01）. TS of schizonepeta volatile oil and paeonol were low, and the four factors were not statistically significant （P〈0.05）. Conclusion Tween-80 assisted solubilize schizonepeta volatile oil and paeonol was less suitable for ultraffltration.