摘要
以4-羟基苯乙酸和3,5-二甲氧基苯酚为原料,通过一条包括苄基化、酰氯化、酯化、氢化、Fries重排、以及Vilsmeier-Haack反应等6步反应的路线合成了天然产物5,7-二甲氧基-4′-羟基异黄酮,目标产物的总收率为33%.利用1HNMR、13C NMR及元素分析确证了化合物的结构.
The natural product 5,7-dimethoxyl-4′-hydroxyisoflavone was synthesized by using a 6-step synthetic protocol including benzylization,acyl chloride forming reaction,esterification,hydrogenation,Fries transformation and Vilsmeier-Haack reaction with 4-hydroxyphenylacetic acid and 3,5-dimethoxyphenol as the starting materials.The overall yield of the target compound was 33%.The structures of the target compounds were confirmed by 1H NMR,13C NMR and elemental analysis.
出处
《化学研究》
CAS
2009年第4期10-13,共4页
Chemical Research
基金
教育部留学回国人员科研启动基金项目
上海市自然科学基金项目(06ZR14001)
