酮络酸复合芬太尼硬膜外术后镇痛的效应观察

The Observation of Ketorolac(NSAID) to Epidural Postoperative Analgesic Effect of Fentanyl (Opioid Drug)

酮络酸为新型强效非类固醇类镇痛抗炎药．本研究拟观察静注酮络酸加强芬太尼硬膜外术后镇痛的效应．结果显示：单纯静注酮络酸或硬膜外芬太尼均有较明显的术后镇痛作用，但仍需辅用较大剂量的哌替啶；而静注酮络酸和硬膜外芬太尼联合用药，则术后镇痛效果明显加强，镇痛持续时间显著延长，哌替啶的用量锐减，恶心、呕吐发生率降低，未出现呼吸抑制现象．本研究还证实酮络酸可加强芬太尼硬膜外术后镇痛的效果，减少其用量，减轻其副作用，为较理想的用药组合．

Ketorolac is a new efficient non steroid anti inflammation drug(NASAID). In this article, we observe the effect of ketorolac on potentiating epidural postoperative analgesia of fentanyl. The results show that a single intravenous injection of ketorolac or a single epidural injection of fentanyl may produce obviously analgesic effect, but must accompany a larger dose of pethidine to get a satisfing effect. The combinative administration of introvenous injection of ketorolac and epidural injection of fentanyl can cause an analgesic effect to be more significant and durable compared with both drugs used singly. The incidence of nausea and vomiting is very low, without respiratory depression. The results reveal that ketorolac can significantly potentiate the analgesic effect of fentanyl, and can reduce its administering dose and adverse effect.