重组牛碱性成纤维细胞生长因子在肛瘘术后创面换药中的应用与护理

rb-bFGF on healing of wound after operation for anal fistula

目的为观察外用重组牛碱性成纤维细胞生长因子(rb-bFGF,商品名贝复济)对肛瘘剖开引流术后创面愈合的影响。方法将96例单纯性肛瘘病人分为治疗组50例,对照组46例,分别应用rb-bFGF和生肌玉红膏纱条换药,观察创面愈合情况。结果创面愈合时间,治疗组(16±1.9)d,比对照组(30±3.2)d明显缩短(P<0.001);创面表皮生长速度,治疗组(5.9±0.6)mm/3d,较对照组(3.1±0.7)mm/3d明显增快(P<0.001)。2组均未见明显全身及局部不良反应。结论外用rb-bFGF可加速肛瘘术后创面愈合过程,减轻患者痛苦,应用安全。

Objective To observe the effect of rb-bFGF（recombinant bovine basic fibroblast growth factor for external use） on healing of the wound after the incision plus drainage for anal fistula. Methods Ninety-six cases of the disease subjected to the operation were divided into treatment group（50 cases）and control group （46 cases）. The former received rb-hFGF for dressing change on their wounds, and the latter received Shengjiyuhonggao ointment gauze for the same purpose. Results The results showed that wound healing time was much shorter in treatment group[（16±1.9）d] than that in control group[ （30±3. 2）d]（P〈0. 001）. The epiderm growth was much faster in treatment group [（5.9±0.6）mm/3d] than that in control groups [（3.1±0.7）mm/3d]（P〈0. 001）, and there was no systemic or local adverse reactions in both the groups. Conclusion It suggests that rb-bFGF can promote the healing of wound alter the operation for anal fistula and relieve pain, and it can he externally used safely.