甲泼尼松龙琥珀酸钠治疗小儿喘憋性肺炎的疗效观察

Efficacy of methylprednisolone sodium succinate treatment of children within asthmatic pneumonia

目的观察甲泼尼松龙琥珀酸钠治疗小儿喘憋性肺炎的疗效。方法将76例喘憋性肺炎患儿随机分为治疗组和对照组,各38例。2组均予以抗病毒、对症治疗(解痉、止咳、平喘,退热,纠正酸碱平衡、维持内环境稳定),抗生素防感染,严重者予以镇静、吸氧,有心力衰竭者予以强心利尿抗心力衰竭治疗。治疗组38例在此基础上加用甲泼尼松龙琥珀酸钠静脉滴注2mg/kg,每天1次;对照组38例在此基础上加用地塞米松0.3mg/kg,每天1次,疗程均为5d。结果治疗组在喘憋、两肺喘鸣和湿啰音消失及住院天数等方面与对照组比较有明显缩短,差异均有统计学意义(P<0.05)。治疗组治愈率为92.1%高于对照组的71.1%,差异有统计学意义(P<0.05)。结论甲泼尼松龙琥珀酸钠治疗小儿喘憋性肺炎疗效好,在治疗过程中未发生不良反应。

Objective Observed the efficacy of methylprednisolone sodium succinate treatment of children with asthmatic pneumonia. Methods 76 cases of children with asthmatic pneumonia were randomly divided into treatment group and control group, all 38 cases. Two groups were to be anti-virus, symptomatic treatment （ spasm, cough, asthma, fever, correct acidbase balance, maintaining a stable internal environment）, treated with antibiotics to prevent from infection, severe patients should to be calm and oxygen, with heart failure patients should to be cardiac anti-diuretic treatment of heart failure. Treatment group ,38 cases on this basis ,was added methylprednisolone sodium succinate intravenous infusion 2mg/kg, onece a day; control group ,38 cases on this basis, dexamethasone 0.3mg/kg, one time a day, treatments were five days. Results In treatment group, asthmatic, lungs wheezing and wet rules disappeared and in-patient clays and so on, compared with the control group had significantly shorter, the differences were statistically significant（ P 〈 0.05 ）. Treatment group, the cure rate was 92.1% higher than 71.1% that of control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion The effecacy of children with asthmatic pneumonia treated by methylprednisolone sodium succinate was good, in the course of treatment without adverse reactions.