226例药品不良反应报告分析

Analysis of 226 Case Reports of Adverse Drug Events in Our Hospital

目的:分析本院药品不良反应报告,为临床安全用药提供参考。方法:采用回顾性分析方法,对本院2006～2008年收集的226例ADR/ADE报告,进行汇总和分析。结果:ADR中女性多于男性(比例:1.66∶1),老年(≥60岁)偏多,占35.40%,;抗微生物药、中药、循环系统药所致ADR排序前三位,其中抗微生物药占69.47%;静脉滴注和口服是引起ADR的主要给药途径,分别占74.34%、21.68%;涉及的人体器官或生理系统主要为皮肤及其附件,占52.69%,其次是消化系统、循环系统。结论:应增强临床医护人员识别、呈报ADR/ADE意识与责任感,做到安全、有效用药。

Objective：To analyze the case reports of drug reactions（ADR/E） in our hospital so as to reduce the incidence of ADR/E resulting from the irrational use of drugs and offer some information about safe drug usage.Method： ADR/E case reports collected between 2006 to 2008 were retrospectively surveyed.According to different kinds of ADR/E, 226 cases with ADR/E were summed up,caculated and analyzed,and the relevance was evaluated for resources and results from ADR/E and irrational use of drugs.Result：The females were more than the males （ 1.68 ： 1 ） and old pationts （ ≥60 岁 ） were more （ 35. 11% ） in the ADR/E ; The categories of antimicrobials, Chinese herbal prepartions and cardiovascular drugs in the ADR/E cases induced by these drugs ranked at the first 3 among all the drugs. Of those, antimicrobials accounted for 69.47%. Most ADR/E cases through intravenous and oral administrations occupied 74.34% and 21.77%. The lesions of ADR/E primarily involved the skin and its accessories （52.69%）, followed by the gastrointestinal system and circulatory system. Conclusion： Clinical workers＇recorgnizing and reporting awareness and responsibility for ADR shoud be strengthened, use these drugs safely and effectively, and alert the incidence of ADR/E.