摘要
在氢氧化钠作用下,1,5-乙酰基-2,4-二氧六氢-1,3,5-三嗪与乙酰溴代糖反应,合成了标题化合物,系统的研究了反应条件对产率的影响,由元素分析、IR和1HNMR确认了所合成糖苷的结构。糖苷的最佳合成条件为:n(乙酰溴代糖)∶n(1,5-乙酰基-2,4-二氧六氢-1,3,5-三嗪)=1∶1,30°C下在丙酮中反应5 h。生测结果表明所合成的化合物具有较好的抗烟草花叶病毒(TMV)的活性。
Glucoside of 1,5-diacetyl-2,4-dioxohexahydro-1, 3,5-triazine was synthesized by the reaction of 1,5-diacety1-2,4-dioxohexahydro-1,3,5-triazine with acetyl glucose bromide in the presence of NaOH. The influence of the reaction conditions on the yield was studied. The structures of the newly synthesized compounds were confirmed by IR,^1H NMR and elemental analysis. The optimum conditions were as follows: acety1 glucose bromide: 1,5-diacety1-2,4-dioxohexahydro-1,3, 5-triazine =1: 1, the reaction temperature was 30℃, the reaction time was 5h and acetone was used as the solvent. Preliminary biological testing indicated that the synthesized glucosides had good antiviral activity against TMV.
出处
《化学世界》
CAS
CSCD
北大核心
2009年第12期737-739,共3页
Chemical World