摘要
目的观察短暂性脑缺血发作(TIA)患者治疗前后血小板膜糖蛋白CD41、CD42b表达的变化。方法采用随机对照试验,观察病例338例,分为清脑通络方组163例,阿司匹林组175例。观察清脑通络方和阿司匹林肠溶片治疗前后TIA患者血浆血小板膜糖蛋白CD41、CD42b表达的变化。应用流式细胞术,测定TIA患者的CD41、CD42b的分子表达。结果两组均有显著降低TIA患者血小板膜糖蛋白CD41表达作用,对CD42b的表达无明显影响;治疗后两组血流变指标有明显改善。结论清肝活血治疗对TIA患者血小板膜糖蛋白CD41表达有显著抑制作用,能明显改善TIA患者的血流变指标。
Objective To study the correlativity of platelet membranee glyeoprotein CD41 and CD421, expression in patients with TIA before and after Qing Nao Tong Luo Fang therapy. Methods The expressions of platelet CD41 ,CD42b were determined by flow cytometry and hemorheological indexes in 338 patients with TIA before and after therapy with Qing Nao Tong Luo Fang and aspirin. There were 163 patients in Qing Nao Tong Luo Fang group and 175 patients in aspirin group. Results CD41 levels in two groups were significantly lower after therapy than before （ P 〈 0.05 ）, CD42b levels in two groups did not significantly change. There was no difference between the patients in Qing Nao Tong Luo Fang group and in aspirin group（ P 〉 0.05 ）. Ameliorate hemorheological indexes changed obviously. Conclusion Qing Nao Tong Luo Fang therapy can inhibit platelet CD41 expression in patients with TIA and improve the ameliorate hemorheological indexes.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第12期2998-2999,共2页
Lishizhen Medicine and Materia Medica Research
基金
广东省自然科学基金(No.010250)
