甲状腺功能亢进症患者血清尿酸水平观察

Level of Serum Uric Acid in Patients with Hyperthyroidism

目的探讨不同性别的甲状腺功能亢进症(甲亢)患者血清尿酸水平变化特点。方法选择在我院住院及部分门诊就诊的120例初诊甲亢患者为观察组,其中男性42例、绝经后女性33例、绝经前女性45例。另选择120例在我院进行体检的健康者为对照组,男性、绝经后女性、绝经前女性各40例。两组受检者均隔夜空腹8h以上测定血清尿酸水平。结果观察组男性、绝经后女性、绝经前女性血清尿酸水平分别为(396±113)μmol/L、(309±128)μmol/L、(316±103)μmol/L,对照组分别为(318±100)μmol/L、(310±105)μmol/L、(267±88)μmol/L,两组男性、绝经前女性血清尿酸水平间差异有统计学意义(P<0.05)。结论男性及绝经前女性甲亢患者血清尿酸水平显著高于健康者,提示甲亢作为一种消耗性疾病,其高代谢状态可导致尿酸代谢异常,使血尿酸水平升高。

Objective To explore the changes of serum uric acid （SUA） level in male or female patients with hyperthyroidism （HT）. Methods One hundred twenty patients preliminarily diagnosed as HT in our hospital were enrolled to observation group （42 males, 33 postmenopausal females, 45 premenopausal） , and another 120 healthy subjects to control （40 males, 40 postmenopausal females, 40 premenopausal）. SUA levels were determined after more than 8 h fasting overnight in 2 groups. Results SUA of males, postmenopausal females and premenopausal were （396 ± 113 ） μmol/L, （309 ± 128 ） μmol/ L, （316 ± 103） μmol/L, respectively, in observation group, and （318 ± 100） μmol/L, （310 ± 105） μmol/L, （267 ± 88） μmol/L, respectively, in control. There was significant difference in SUA between males and premenopausal females in 2 groups （P 〈 0. 05）. Conclusion SUA levels of male and premenopausal female HT patients are significantly higher than those of healthy subjeets, suggesting that HT is wasting disease, and its high metabolic state may lead to abnormal uric acid metabolism to raise SUA levels.