卡维地洛对老年舒张性心力衰竭患者心功能及糖、脂代谢的影响

Effect of carvedilol on heart function and glucolipometabolic in elder patients with diastolic heart failure

目的:探讨卡维地洛对老年舒张性心力衰竭(DHF)患者心功能及糖、脂代谢的影响,阐明其改善心功能的作用。方法:将76例老年舒张性心力衰竭的患者随机分为治疗组34例及对照组42例,全部给予常规抗舒张性心力衰竭治疗,治疗组加用卡维地洛(从小剂量开始),疗程3～6个月。应用超声心动图(UCG)及无创心功能检测仪(Bioz.com)测定两组治疗前后心脏舒张功能指标。检测两组空腹血糖及甘油三酯、胆固醇水平。结果:治疗组患者在治疗后总有效率明显高于对照组(P<0.05),反映左室舒张功能的指标优于治疗前(P<0.05),与对照组比较差异有显著性(P<0.05)。治疗组用药前后血糖、血脂变化差异无显著性(P>0.05),与对照组比较血糖、血脂均降低(P<0.05)。治疗过程中,两组均未发生明显不良反应,无一例停药。结论:应用卡维地洛可改善老年舒张性心力衰竭患者的左室功能,且对糖、脂代谢无明显影响。

Objective To discuss the effects of carvedilol on the heart function and glucolipometabolism in elder patients with diastolic heart failure.Methods 76 elder patients with diastolic heart failure were randomly divided into treatment group（n=34） and control group（n=42）,all the patients were given routine treatment of diastolic heart failure,the patients in treatment group were given carvediol in addition（ from little dose to more ）,the course of treatment was 3-6 months.The parameters of the diastolic function of heart before and after treatment in two groups were determined by ultrasonic cardiogram and uninjured cardiodynamic machine.And the levels of fasting blood glucose,triacylglucerol（TG）,cholesterol in two groups were detected.Results After treatment the total effective rate in treatment group was higher than that in control group（ P〈0.05）.There was no significant difference of blood glucose and lipid between before and after treatment in treatment group.But compared with control group,the levels of blood glucose and lipid in treatment groupo were decreased（P〈0.05）.During the treatment there was no significant adverse effects in two groups,no stopping treatment.Conclusion Carvedilol could improve the function of left ventricle of elder patients with diastolic heart failure,and has no significant effects on the metabolism of glucose and lipid.