孕激素受体A、B在乳腺癌和癌旁乳腺组织中的表达及其意义

Expressions of progesterone receptor A and B in breast cancer and adjacent non-malignant tissues and significances

目的:探讨孕激素受体A、B(PRA、PRB)在乳腺癌和癌旁非恶性乳腺组织(癌旁组织)中的表达及其与患者临床特征之间的关系。方法:采用免疫组织化学方法检测PRA和PRB在50例(全部为女性)乳腺癌及癌旁乳腺组织中的表达,分析PRA、PRB表达与患者年龄、雌激素受体α(ERα)和CDC-47之间的关系。结果:PRA和PRB在癌细胞和癌旁上皮细胞及导管上皮细胞的细胞核及细胞浆中均有表达,阳性率分别为42%、42%和52%、36%,PRA与PRB在癌组织和癌旁组织中表达阳性率比较差异无显著性(P>0.05)。癌旁组织中PRA表达与年龄呈明显负相关(r=-0.3168,P<0.05);癌组织中PRA和PRB的表达与ERα(r=0.4032,P<0.05;r=0.3786,P<0.05)及CDC-47(r=-0.4228,P<0.05;r=-0.5295,P<0.05)表达明显相关;在癌组织和癌旁组织中,PRA与PRB均呈显著正相关(r=0.8401,P<0.05;r=0.4246,P<0.05)。结论:孕激素受体两种亚型相互协调行使功能,但PRA在乳腺癌发生及发展中起更加重要的作用。

Objective To study the expressions of progesterone receptor A （PRA） and B （PRB） in breast cancer and adjacent non-malignant tissues and the correlations between their expressions and the clinical characteristics. Methods The expressions of PRA and PRB in 50 specimens of female human breast cancer and adjacent non-malignant tissues were detected by immunohistochemistry. The correlations between the expressions of PRA and PRB and the clinical characteristics were analyzed.Results PRA and PRB expressed in both the nuclei and the cytoplasma of tumor cells and epithelial cells of the acini and ducts.The percentages of PRA and PRB positive cells were 42%,42% and 52%,36% in the cancer and the adjacent non-malignant tissues,respectively,there was no significant difference.The expression of PRA was significantly correlated with the age of patient（r=-0.316 8,P〈0.05） in adjacent non-malignant tissues.The expressions of PRA and PRB were significantly correlated with the expression of CDC-47（r=-0.422 8,P〈0.05;r=-0.529 5,P〈0.05）and ERα（r=0.403 2,P〈0.05;r=0.378 6,P〈0.05） in malignant tissues.The expressions of PRA in malignant tissue or adjacent non-malignant tissues were significantly correlated with the expression of PRB （r=0.840 1,P〈0.05;r=0.424 6,P〈0.05）. Conclusion PRA and PRB have synergetic effect,but PRA may play a more important role in the development and progression of breast cancer.